Osteoporosis is a progressive condition that weakens bones, increasing the risk of fractures, especially in the hip, spine, and wrists. One of the most advanced treatment options available today is the Prolia injection for osteoporosis — a biannual medication that helps prevent bone loss and strengthens the skeletal system. Whether you’re considering Prolia for the first time or researching options for a loved one, this guide explores the benefits, side effects, cost of Prolia shot, and answers questions like “Is Prolia covered by Medicare Advantage Plan?”

Understanding Prolia and Osteoporosis Treatment

Prolia, also known by its generic name denosumab, is a prescription medication used to treat osteoporosis in postmenopausal women and men at high risk of fracture. Unlike daily pills, Prolia for osteoporosis is given via injection every six months, offering consistent and long-term protection for bone health.

Benefits of Prolia for Osteoporosis

• Significantly increases bone density in the hip and spine.


• Reduces the risk of fractures in those with low bone mass.


• Convenient bi-annual dosing compared to daily or weekly pills.


• Alternative for individuals who cannot tolerate oral bisphosphonates.


• FDA-approved for men and women at high risk for fractures.

Comparing Osteoporosis Treatments

• Bisphosphonates (e.g., alendronate, risedronate) — Oral medications that slow bone loss.


• Hormone Therapy — Mainly for postmenopausal women.


• SERMs — Selective estrogen receptor modulators for bone density.


• Prolia injections for osteoporosis — Injectable treatment with long-lasting effects.

Diagnosing Osteoporosis Before Prolia

To determine if Prolia is appropriate, doctors may recommend:

• DEXA scan — Measures bone mineral density.


• X-rays — Detects fractures caused by weakened bones.


• Blood tests — To check calcium, vitamin D, and hormone levels before Prolia injection.

Prolia Injection: How It’s Administered

• Prolia injection dose: 60 mg injected subcutaneously every six months.


• Prolia administration sites: Arm, thigh, or abdomen.


• Can be administered by a healthcare professional or self-injected in some cases.


• Important to schedule doses on time — don’t delay or miss them.


• Ask your doctor: “Can you take Prolia one month early?” for any schedule changes.

Duration & Post-Prolia Transition

• How long can you take Prolia? Often prescribed for several years, but needs monitoring.


• What to take after stopping Prolia? A transition plan is crucial to prevent rapid bone loss.


• Discontinuing Prolia for osteoporosis without follow-up medication can lead to fractures.

Side Effects and Risks of Prolia

Common Prolia Side Effects:

• Joint pain, back pain, fatigue.


• Prolia back pain and stiffness are reported by some users.


• Rare but serious risk: osteonecrosis of the jaw (ONJ).


• Inform your dentist and surgeon before procedures — Prolia can impact healing.


• Does Prolia cause weight gain? Some users report this, but it’s not a common side effect.

Cost of Prolia Shot: What You Should Know

• The cost of Prolia shot without insurance can range from $1,300 to $2,800 per injection.


• Prolia injection cost with insurance depends on your plan’s coverage.


• Manufacturer savings programs and Prolia coupons may lower out-of-pocket costs.


• Medicare patients may qualify for financial assistance or Extra Help programs.

Is Prolia Covered by Medicare Advantage Plan?

• Is Prolia covered by Medicare Advantage Plan? In many cases, yes.


• Coverage can fall under Medicare Part B or Part D, depending on how it’s administered.


• Does Medicare cover Prolia injection? If deemed medically necessary, yes.


• Check your plan’s formulary to confirm Prolia cost Medicare responsibilities.


• Medicare Part B may cover it when administered in a medical setting, while Part D may cover pharmacy pickups.

How often will Medicare pay for Prolia injections?

• Every six months, as prescribed.